Break dosage, cell cycle stage and DNA replication influence DNA double strand break response
نویسندگان
چکیده
منابع مشابه
Break dosage, cell cycle stage and DNA replication influence DNA double strand break response
DNA double strand breaks (DSBs) can be repaired by non-homologous end joining (NHEJ) or homology-directed repair (HR). HR requires nucleolytic degradation of 5' DNA ends to generate tracts of single-stranded DNA (ssDNA), which are also important for the activation of DNA damage checkpoints. Here we describe a quantitative analysis of DSB processing in the budding yeast Saccharomyces cerevisiae....
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2008
ISSN: 0261-4189,1460-2075
DOI: 10.1038/emboj.2008.111